Meet the Cast of Weird Science

"Weird Science" is a fantastical coming-of-age comedy that revolves around the lives of two socially awkward teenagers, Gary Wallace and Wyatt Donnelly. Played by John Asher and Michael Manasseri, respectively, these characters embody the struggles and insecurities of adolescence, often becoming targets of bullying from their more aggressive classmates. Gary is portrayed as a dreamer, harboring aspirations of a perfect romantic partner and an idealized life, while Wyatt is the quintessential geek, shy and reserved, often overshadowed by his more outgoing friend. Their friendship, though tested by the harsh realities of high school life, serves as the foundation for their wild and imaginative exploits.

In a moment of desperation to escape their mundane existence and the constant torment they face, Gary and Wyatt turn to science for a solution. Utilizing a computer and a rather strange combination of electrical radiation, they stumble upon a bizarre method to create the ultimate fantasy woman. This leads to the entrance of Lisa, a stunning and enchanting creation with the power to make their dreams come true. Lisa, portrayed with charisma and flair, becomes the catalyst for the transformation of Gary and Wyatt's lives, proving herself to be more than just a mere figment of their imaginations. Instead, she emerges as a confidante and a mentor, teaching the boys valuable lessons about self-confidence and embracing their identities.

As the narrative unfolds, "Weird Science" brilliantly navigates the complexities of teenage life through humor and heartwarming moments. The film cleverly contrasts the boys' initial shallow desires with the more profound truths that Lisa helps them uncover about friendship, love, and acceptance. Through chaotic escapades and comedic mishaps, Gary and Wyatt learn that true fulfillment comes from within, and they discover that being themselves is the most rewarding path to take. The film resonates with audiences, not just as a light-hearted comedy, but as a poignant reminder of the trials of adolescence and the importance of embracing one’s individuality.

Weird Science ran for 5 seasons.

Main Cast of Weird Science

Michael Manasseri

as Wyatt Donnelly (88 episodes)

Michael Manasseri's portrayal of Wyatt Donnelly in the television adaptation of "Weird Science" is a vibrant homage to the original character created by John Hughes. Manasseri brings a charming awkwardness and an endearing vulnerability to the role, expertly capturing the essence of a teenager grappling with the trials and tribulations of adolescence. His performance is characterized by a natural comedic timing that beautifully complements the show's quirky humor. As Wyatt, Manasseri embodies the everyman appeal of the high school underdog, making him a relatable and rootable character for viewers. His chemistry with his co-star, Vanessa Angel, who plays the enigmatic Lisa, adds a dynamic layer to the show, as their interactions highlight Wyatt's transition from a shy, insecure boy to a more confident young man, thanks to the extraordinary influence of his magically engineered dream woman. Manasseri's ability to balance humor with heartfelt moments cements his rendition of Wyatt Donnelly as a memorable and beloved figure in the annals of 90s teen sitcoms.

John Asher

as Gary Wallace (88 episodes)

John Asher brought the character of Gary Wallace to life in the television adaptation of "Weird Science," a role that was originally portrayed by Anthony Michael Hall in the 1985 film of the same name. Asher embraced the quirky and awkward nature of Gary, one half of the nerdy duo who create the perfect woman, Lisa, through a combination of computer science and supernatural intervention. His performance balanced the character's social ineptitude with a genuine charm and enthusiasm, capturing the essence of a teenager driven by hormones and a desire for acceptance. Asher's portrayal resonated with the struggles of adolescence, making Gary relatable and endearing to the show's audience. His comedic timing and chemistry with the cast, particularly with Lee Tergesen who played his best friend Wyatt, contributed to the show's cult following. Asher's Gary was a testament to the actor's ability to honor the spirit of the original character while infusing it with his own unique flair.

Vanessa Angel

as Lisa (88 episodes)

Vanessa Angel brought a unique blend of charm and sophistication to the role of Lisa in the television adaptation of "Weird Science," a character originally portrayed by Kelly LeBrock in the 1985 film of the same name. Angel's Lisa was a high-tech, computer-generated dream girl who emerged from the computer screens of two nerdy teenagers, Gary (John Mallory Asher) and Wyatt (Michael Manasseri), to transform their lives with her magical abilities and sage advice. While staying true to the enigmatic and nurturing essence of the character, Angel infused Lisa with her own brand of allure, exuding a graceful confidence that made her both an aspirational figure and a believable guardian to the show's young protagonists. Her performance was notable for its blend of wit, understanding, and a touch of otherworldly mystique, which endeared her to audiences and made her an integral part of the show's enduring appeal. Angel's Lisa was not just a fantasy figure but a caring mentor, guiding the boys through the trials of adolescence with a mix of wisdom, humor, and, when necessary, a bit of supernatural intervention.

Lee Tergesen

as Chett Donnelly (88 episodes)

Lee Tergesen's portrayal of Chett Donnelly in the television series "Weird Science" is a memorable one, encapsulating the quintessential high school bully with a layer of comedic flair. As Chett, Tergesen brought to life a character that was both intimidating and absurd, often finding himself in outlandish situations as a result of the experiments and hijinks of the two protagonists, Gary and Wyatt. His performance was characterized by a brutish demeanor, an iconic sneer, and a booming voice that commanded attention. Tergesen managed to balance Chett's menace with a surprising vulnerability, revealing the insecurities that often underpin the bully archetype. His interactions with the cast, particularly his dynamic with Gary (played by Anthony Michael Hall), were filled with tension and humor, making Chett a character that audiences loved to hate but also couldn't help but laugh at. Lee Tergesen's ability to bring depth and humor to Chett Donnelly solidified his role as a standout character in the show, contributing to the series' enduring charm and nostalgia.

Secondary Cast of Weird Science

Steve Susskind

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Carrie Stevens

Lyman Ward

Lauren Tewes

Christopher Mayer

Krystee Clark

Michael Bower

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Julie Condra

Seth Green

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Michael Deak

Nathan Lawrence

Dwight Schultz

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Lisa Canning

Lawrence Hilton-Jacobs

Adrienne Barbeau

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Leslie Jordan

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Persia White

Deborah Kellner

John Michael Higgins

Morwenna Banks

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James Lew

Charlotte Ayanna

Denise Richards

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Phil Buckman

as Roger (5 episodes)

Kevin Michael Richardson

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Bruce Jarchow

Jamie Rose

Jennifer Aspen

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Jeff Doucette

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Ted Lange

Joseph Whipp

Michael Buffer

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Adam Wylie

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Gerrit Graham

Heather McComb

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Brittney Powell

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Kevin Brief

Melanie Chartoff

Diane Klimaszewski

Heidi Sorenson

Charles Fleischer

Stacie Mistysyn

Dick Miller

Robert Curtis Brown

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Emma Caulfield Ford

Lea Moreno Young

Gloria LeRoy

Sofia Milos

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June Foray

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Jake Johannsen

Burton Gilliam

James Daughton

Jeremy Roberts

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Cindy Ambuehl

Matthew Linville

Ryan Stiles

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Larry Hankin

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Michael Dempsey

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Felicity Waterman

Marisa Coughlan

Kenneth Mars

Chad Cox

Kari Lizer

Andrew Prine

Eddie Mekka

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Jarrad Paul

Robin McKee

Barry Dennen

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Rick Scarry

Ed Gale

Abe Vigoda

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Mark Lindsay Chapman

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Edward Winter

Todd Susman

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William Bumiller

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Elaine Klimaszewski

Brigitta Dau

Jennifer Aquino

Joshua Boyd

Ritch Brinkley

Raymond Guth

Brian Thompson

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Dennis Fimple

Larry Gelman

Andre Rosey Brown

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Nicki Aycox

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Paul Ainsley

Robert Feeney

Maura Soden

Clayton Norcross

Robyn Bliley

John Mariano

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Larry Poindexter

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Owen Bush

Krista Allen

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Peter Siragusa

Nigel Gibbs

Andrew Kavovit

Rick Zieff

Wendy J. Cooke

Daniel Keough

as Agent Clint (1 episode)

Elmarie Wendel

as Mrs. Wilder (1 episode)

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Ashley Nation

as 1986 Julia Putnam (1 episode)

Rex Ryon

as Bouncer (1 episode)

K. Jill Sorgen

as Linda (1 episode) , Kelly (1 episode)

Cynthia Madvig

as Shelly / Rachel (2 episodes)

Rachel Parker

as Gariette (1 episode)

Jennifer Manasseri

as Wynona (1 episode)