
Out West unfolds in the rough-and-tumble setting of the western town Mad Dog Gulch, where Arbuckle finds himself abruptly ejected from a train and subsequently pursued by a group of Native Americans. This unexpected and perilous arrival sets the stage for a comedic and adventurous tale filled with action and camaraderie.
Upon reaching Mad Dog Gulch, Arbuckle joins forces with Bill Bullhum, a charismatic gambler and saloon owner well-acquainted with the town's challenges. Together, they strive to protect Salvation Sue, a devoted Salvation Army worker, from the nefarious intentions of the town's villain, Wild Bill Hickup. Their alliance highlights themes of friendship and justice amid the frontier's chaos.
Throughout the story, Arbuckle and his companion Buster engage in a series of humorous escapades aimed at outwitting their adversaries, especially the crafty St. John. Their efforts culminate in the discovery of St. John's unexpected vulnerability—his ticklishness—which becomes a pivotal element in tipping the scales in their favor. The narrative combines slapstick humor with Western motifs, delivering an entertaining and lighthearted experience.