Man to Man with Dean Learner is a British comedy chat show that was first broadcast on Channel 4 on 20 October 2006 and released on DVD on 3 September 2007. It features comedians Richard Ayoade and Matthew Holness.

Originally called Deano's After Dark, the show features Dean Learner chatting to a range of guests including Merriman Weir and Garth Marenghi.