Best of the Worst was a British panel game, which was broadcast on Channel 4 in 2006. The show was created by Giles Pilbrow and Colin Swash.

Hosted by Alexander Armstrong, it featured two teams of two players, one captained by David Mitchell and the other by Johnny Vaughan. The other panellists were either comedians or well known television personalities.

The show looked at the worst things ever to happen in the world, such as the person with the worst luck, the worst diet, or the worst inventions.